Table 9.
Pathways of mRNAs in the ceRNA networks in SCLC.
| mRNAs | Gene ontology (GO) based on molecular function | Pathways | Associated to SCLC pathway |
|---|---|---|---|
| Colony-stimulating factor 3 receptor (CSF3R) | Cytokine binding (GO:0019955) | Autophagy pathway | Güçlü E, et al. (56); Liu H, et al. (57) |
| Cytokine receptor activity (GO:0004896) | Akt signalling | na | |
| Protein binding (GO:0005515) | PEDF-induced signalling | na | |
| Signalling receptor activity (GO:0038023) | Cytokine signalling in the immune system | na | |
| Granulocyte colony-stimulating factor binding (GO:0051916) | Hematopoietic cell lineage | na | |
| Acid alpha-glucosidase (GAA) | Catalytic activity (GO:0003824) | Glucose metabolism | Yan X, et al. (58) |
| Hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553) | Innate immune system | na | |
| Alpha-1,4-glucosidase activity (GO:0004558) | Galactose metabolism | na | |
| Hydrolase activity (GO:0016787) | Metabolism | na | |
| Hydrolase activity, acting on glycosyl bonds (GO:0016798) | Lysosome | na | |
| FGR Proto-Oncogene, Src Family Tyrosine Kinase (FGR) | Nucleotide binding (GO:0000166) | Innate immune system | na |
| Phosphotyrosine residue binding (GO:0001784) | Platelet homeostasis | na | |
| Protein kinase activity (GO:0004672) | Tyrosine kinases/adaptors | na | |
| Protein tyrosine kinase activity (GO:0004713) | CCR5 pathway in macrophages | na | |
| Transmembrane receptor protein tyrosine kinase activity (GO:0004714) | Integrin pathway | na |
ceRNA, competing endogenous RNA; SCLC, small cell lung cancer; Akt, protein kinase B; CCR5, chemokine-CC motif-receptor-5; GO, gene ontology; PEDF, pigment epithelium derived factor; na, not available.