Table 1.
Clinical features of isolated gonadotropin deficiency in males and females
| Isolated LH deficiency 17 | Isolated FSH deficiency 18 | ||
|---|---|---|---|
| General features | Fertility | General features | Fertility |
| Males | |||
| Under‐virilisation or delayed puberty, eunuchoid body proportions, gynaecomastia | Comparatively large testes volumes for serum testosterone, +/− oligospermia with arrested spermatogenesis | Normal or delayed puberty, small, soft testes | Azoospermia, or oligospermia with abnormal morphology |
| Isolated LH deficiency 19 | Isolated FSH deficiency 20 | ||
|---|---|---|---|
| General features | Fertility | General features | Fertility |
| Females | |||
| Normal pubertal development with menarche | Oligomenorrhoea with lack of ovulation | Delayed or arrested breast and uterine development | Amenorrhoea, with ovarian follicular development arrested at preantral stage |
Abbreviations: FSH, follicle‐stimulating hormone; LH, luteinizing hormone.