Table 3.

Causes of precocious puberty

Girls		Boys
Central	Peripheral	Central	Peripheral
Idiopathic	Secondary to adrenal androgens, for example, congenital adrenal hyperplasia	Benign or malignant lesion of CNS, for example, astrocytoma, glioma	Secondary to adrenal androgens, for example, congenital adrenal hyperplasia
Genetic, for example, MKRN3 mutations	McCune‐Albright syndrome	H–P damage, for example, radiotherapy, birth asphyxia, hydrocephalus	Testotoxicosis (activating mutation of the LHCGR)
Hypothalamic hamartoma or other CNS lesion or damage	Ovarian cyst or ovarian/adrenal tumour	Genetic, for example, MKRN3 mutations	McCune‐Albright syndrome
		Idiopathic	Testicular or adrenal tumour

Abbreviations: CNS, central nervous system, H–P, hypothalamic–pituitary; LHCGR, luteinizing hormone/chorionic gonadotropin receptor.