Table 2.

Versican-associated secreted factors

Inflammatory Mediator	GAGs and PGs that Interact	References
CXC-Chemokines
CXCL1, CXCL2, CXCL3, CXCL4, CXCL8, CXCL10, CXCL12	HS, CS, HSPGs, and CSPGs	(57–61)
CC-Chemokines
CCL2, CCL3, CCL4, CCL5, CCL11	HS, collagen XVIII, and versican	(57–59, 62–65)
Proinflammatory cytokines
IL-1α IL-1β, IL-2, IL-5, IL-6, IL-7, IL-12, TNFα, IFNγ	HS, heparin, perlecan, CD44v3, CSPGs	(66–75)
Anti-inflammatory cytokines
IL-4, IL-10, IFNβ	HS	(76, 77)
Growth factors
FGFs, VEGF, GM-CSF, TGFβ	HS and heparin	(78–83)

Adapted with permission from Kang et al. (17). CS, chondroitin sulfate; CSPG, chondroitin sulfate proteoglycan; GAG, glycosaminoglycan; PG, proteoglycan.