Table 1.

Differential expressions in IBS-D compared with IBS-C of the same genes that were upregulated in both right and left colonic mucosa

		Right Colon			Left Colon
Mucosal Function	Gene Symbol	Gene function	Log2-fold change	P adj	Log2-fold change	P adj
Inflammation or immune function
Lymphocyte development	CD19	B cell development	1.021	0.008	1.137	6.70E-05
	IKZF3	Lymphocyte differentiation	1.411	9.87E-06	1.414	2.17E-08
	CXCR5	Lymphocyte differentiation	1.479	0.006	1.185	0.003
B or T lymphocyte function and differentiation	CD79B	B lymphocyte receptor	1.078	0.002	1.107	2.33E-05
	CD22	B lymphocyte inhibition	1.533	0.0001	1.465	9.13E-07
	CHI3L2	Stimulation of type 2 T helper lymphocytes	1.237	0.005	1.176	0.0003
	CR2	Participates in B lymphocyte activation	1.624	0.002	1.697	3.54E-05
	BANK1	B lymphocyte function	1.112	0.002	1.109	0.0002
	FCRL3	Fc receptor-like genes expressed in B lymphocytes	1.535	0.0004	1.349	0.0001
	FCRL1		1.415	0.01	2.005	6.25E-07
	MS4A1 (CD20)	Differentiation of B-cell to plasma cell	1.514	0.006	1.288	0.006
Chemokines and immune activation	CCL23	Chemokine	1.739	2.52E-05	1.176	0.001
	CXCL13	Chemokine	1.742	0.006	1.368	0.0143
	CTLA4	Immune checkpoint	1.486	0.0001	1.039	0.010
	PILRB	Immune activation	1.201	0.0001	1.645	1.53E-06
	MAP3K14	NFκB-inducing kinase	1.011	1.79E-06	1.005	5.6E-08
	TCL1A	Associated with NFκB	2.024	0.002	1.752	0.002
	TLR10	Pathogen recognition	1.103	0.006	1.343	1.39E-05
	TNFSF11	Encodes a member of the TNF cytokine family	1.312	0.007	1.170	0.0002
Receptors and ion channels
	P2RX5	Purinoceptors for ATP	1.284	0.0002	1.433	9.33E-08
	CNR2	Cannabinoid receptor 2	1.064	0.009	1.096	0.0002
	GABRE	GABA-A receptor subunit epsilon	1.244	0.0002	1.105	0.002
	RNF207	Expression of K+ channel KCNH2	1.254	0.0003	1.099	0.001
Visceral hypersensitivity
	TRPV1	TRPV1 channel: nociception	1.384	0.0002	1.373	2.41E-06
Miscellaneous
	DNHD1	Aka C11orf47: microtubule motor activity	1.154	0.0006	1.047	0.0001
	COL27A1	Fibrillar collagens	1.261	0.0003	1.241	0.00001

IBS, irritable bowel syndrome.