Table 2.
Differential expressions of genes (up- or downregulated) in IBS-D compared with IBS-C that were different in right and left colonic mucosa
| Right Colon |
Left Colon |
|||||||
|---|---|---|---|---|---|---|---|---|
| Mucosal Function | Gene symbol | Gene function | Log2-fold change | P adj | Gene symbol | Gene function | Log2-fold change | P adj |
| Upregulated | ||||||||
| Immune function | LTF | Neutrophil lactotransferrin | 1.412 | 0.004 | BLK | B lymphocyte development, differentiation, signaling | 1.161 | 1.39E-05 |
| IL21R | Interleukin receptor | 1.018 | 1.76E-05 | |||||
| TRDV1 | Antigen recognition by T lymphocytes | 1.002 | 0.048 | |||||
| LY6G5B | Leukocyte antigen-6 gene in MHC class III | 1.260 | 0.0008 | |||||
| Receptor | GABBR1 | GABA-B receptor subunit 1 | 1.012 | 0.003 | ||||
| membrane channels | SLC6A7 | Terminates action of proline, Na+ re-uptake, l-proline transporter | 1.221 | 0.003 | ABCA10 | Translocation of substrates across cellular membranes | 1.085 | 0.013 |
| YJEFN3 | Cholesterol efflux | 1.576 | 0.001 | |||||
| Cellular transcription or migration | RLTPR | aka CARMIL2B: controls cell migration | 1.205 | 1.76E-05 | ||||
| PARP15 | Transcription repressor | 1.144 | 0.0002 | |||||
| Downregulated | ||||||||
| Protease activity | PI15 | Peptidase inhibitor | −1.046 | 0.008 | PI16 | Protease inhibitor | −1.995 | 2.62E-05 |
| Receptors | GABRB3 | GABA-B receptor subunit 3 | −1.08 | 0.001 | ||||
| VIP | VIP receptor | −1.35 | 0.018 | |||||
| Structural | OLFM4 | Facilitates cell adhesion | −1.177 | 0.008 | ||||
| DES | Desmin (DES): a muscle scaffolding protein that also anchors mitochondria | −1.149 | 0.0001 | |||||
IBS, irritable bowel syndrome. Overlap represents the number of genes in specific pathways (metabolism, synthesis, activation) showing differential expression among total number of genes in that pathway.