Table 3.
Pathway analyses identified as different, based on differential expressions in left colon mucosa in IBS-D compared with IBS-C
| Pathway Term | Overlap | P adj | Odds Ratio | Combined Score | Genes | DE | Confirmation of Category |
|---|---|---|---|---|---|---|---|
| Tyrosine metabolism | 1/36 | 0.041 | 95.0 | 416.2 | TYRP1 | Down | KEGG_2019_ Human |
| Glycosaminoglycan (mucopolysaccharide) biosynthesis | 1/53 | 0.041 | 63.9 | 255.3 | HS3ST2 | Down | KEGG_2019_ Human |
| B cell activation | 6/73 | 0.021 | 10.7 | 108.2 | FCRL1; CD79B; CR2; BANK1; JAK3; MS4A1 | Up | Gene Ontology _Biological Process_2018 |
IBS, irritable bowel syndrome; DE, differential expressions; up, upregulated; down, downregulated.