Table 4.
Differential gene expressions in terminal ileal mucosa in patients with IBS-C or IBS-D compared with normal healthy volunteers
| Gene Symbol | Gene Function | Log2-Fold Change | P adj | DE |
|---|---|---|---|---|
| IBS-C compared with health controls | ||||
| RERGL | G Protein activity | −1.853 | 0.042 | Down |
| MFAP5 | Vascular growth factor | −1.128 | 0.037 | Down |
| SDS | Represses transcription and augments histone deacetylase activity | 1.057 | 0.030 | Up |
| PLA2G7 | Inflammatory and oxidative stress response | 1.024 | 0.022 | Up |
| IBS-D compared with healthy controls | ||||
| RERGL | G Protein activity | −1.698 | 0.028 | Down |
| MFAP5 | Vascular growth factor | −1.146 | 0.028 | Down |
| PILRB | Paired immunoglobulin-like type 2 receptor β, in immune function | 1.458 | 0.044 | Up |
| EML6 | Microtubular assembly | 1.303 | 0.028 | Up |
| NBPF12 | Neuroblastoma breakpoint family member 12; possibly neural development | 1.290 | 0.041 | Up |
DE, differential expressions; up, upregulated; down, downregulated.