Table 5.
Differential expressions in colonic mucosa for IBS-D compared with healthy controls
| Mucosal Function | Gene Symbol | Gene Function | Log2-Fold Change | P adj | DE |
|---|---|---|---|---|---|
| Right colon mucosa | |||||
| Inflammation/immune | PILRB | Immune regulator | 1.444 | 6.08E-05 | Up |
| IKZF3 | Lymphocyte differentiation | 1.082 | 0.002777 | Up | |
| LY6G5B | Lymphocyte antigen-6 gene in MHC class III | 1.545 | 0.00031 | Up | |
| CCL21 | Chemokine | −1.051 | 3.39E-02 | Down | |
| CXCL1 | Antimicrobial chemokine | 1.778 | 1.49E-05 | Up | |
| CXCL2 | Chemokine | 1.515 | 2.87E-04 | Up | |
| CXCL3 | Chemokine | 1.264 | 0.001805 | Up | |
| NFKBIZ | Transcriptional regulator for NFκB | 1.249 | 5.11E-06 | Up | |
| TNFRSF25 | TNF receptor; immune | 1.005 | 0.008753 | Up | |
| ZC3H12A | Inflammation, immune homeostasis | 1.243 | 7.02E-07 | Up | |
| Cell development and transcription | ZNF713 | Transcriptional regulation | 1.224 | 0.000548 | Up |
| ZNF785 | Transcriptional regulation | 1.156 | 1.16E-05 | Up | |
| EGR1 | Transcription | 1.535 | 6.93E-05 | Up | |
| FOS | Cell development | 1.367 | 0.000306 | Up | |
| HBEGF | Growth factor | 1.020 | 8.58E-05 | Up | |
| TLCD2 | Plasma membrane composition | 1.244 | 1.10E-06 | Up | |
| SOAT2 | Formation of fatty acid-cholesterol esters (less soluble in membranes than cholesterol | −2.434 | 0.000235 | Down | |
| CALB2 | Intracellular Ca-binding protein | −1.605 | 9.98E-05 | Down | |
| MS4A10 | Signal transduction | −1.370 | 0.031217 | Down | |
| Serine proteases | PI15 | Trypsin inhibitor | −1.241 | 2.19E-03 | Down |
| TMPRSS15 | Serine protease | −3.439 | 2.51E-04 | Down | |
| Receptors and Ion/nutrient channels | GABRE | GABA receptor | 1.087 | 1.25E-02 | Up |
| RNF207 | Potassium channel KCNH2 | 1.223 | 4.25E-03 | Up | |
| TRPV1 | Receptor, sensation | 1.306 | 0.000694 | Up | |
| VIP | Neurotransmitter | −2.415 | 2.40E-05 | Down | |
| SCNN1G | Na+ permeable non-voltage-sensitive ion channel | 2.361 | 1.69E-04 | Up | |
| SLC6A7 | Na+ reuptake l-proline transporter | 1.299 | 4.35E-03 | Up | |
| SLC6A19 | Epithelial resorption of neutral amino acids | −1.243 | 0.008506 | Down | |
| SULT2A1 | Sulfonation of bile acids | −3.074 | 2.49E-03 | Down | |
| Left colon mucosa | |||||
| Inflammation/immune | CCL3L3 | Chemokine ligand | 1.286 | 0.002 | Up |
| CCR4 | Chemokine receptor | 1.030 | 0.002 | Up | |
| CXCR5 | Chemokine receptor | 1.020 | 0.031 | Up | |
| CD22 | B cell receptor signaling | 1.095 | 0.001 | Up | |
| CR2 | Complement receptor | 1.043 | 0.016 | Up | |
| FCRL1 | Fc receptor | 1.592 | 8.5E-05 | Up | |
| IL1B | Interleukin | 1.003 | 0.0008 | Up | |
| LY6G5B | Lymphocyte antigen-6 gene in MHC class III | 1.270 | 0.003 | Up | |
| IKZF3 | Lymphocyte differentiation | 1.277 | 7.66E-05 | Up | |
| PILRB | Immunoglobulin-like receptor | 1.433 | 0.000126 | Up | |
| TNFRSF9 | Cytokine-related | 1.097 | 0.003524 | Up | |
| TNFSF11 | Cytokine-related | 1.219 | 0.000506 | Up | |
| NFKBIZ | Inhibitor of NFκB | 1.062 | 4.88E-06 | Up | |
| Differentiation/ cell development | EGR1 | Early growth factor | 1.042 | 0.018849 | Up |
| EGR2 | 1.070 | 0.00621 | Up | ||
| EGR3 | 1.245 | 0.001438 | Up | ||
| HBEGF | EGF-like growth factor | 1.254 | 0.000223 | Up | |
| TLCD2 | Composition and fluidity of the plasma membrane | 1.081 | 5.07E-06 | Up | |
| MUC17 | Cell surface mucin | 1.317 | 0.00088 | Up | |
| Neurotransmitters | GABRE | GABA receptor | 1.147 | 0.00195 | Up |
| TRPV1 | Visceral hypersensitivity | 1.572 | 1.04E-05 | Up | |
| VIP | Neurotransmitter | −1.552 | 0.000213 | Down | |
| Receptors/channels | GPR132 | Cellular proliferation | 1.030 | 0.000127 | Up |
| GPR157 | Secretin and VIP receptor | 1.009 | 4.01E-06 | Up | |
| RNF207 | Potassium channel KCNH2 | 1.056 | 0.005411 | Up | |
| SCNN1G | Sodium channel | 1.068 | 0.020921 | Up | |
| SLC6A7 | Na+ reuptake l-proline transporter | 1.054 | 0.001661 | Up | |
| NR4A2 | Receptor protects dopaminergic neurons | 1.098 | 0.000671 | Up | |
| P2RX5 | Purinergic receptor | 1.045 | 0.000106 | Up | |
| Protease | PI16 | Protease inhibitor | −2.044 | 1.2E-06 | Down |
DE, differential expressions; up, upregulated; down, downregulated.