Table 6.
Differential expressions in colonic mucosa for IBS-C vs. healthy controls
| Mucosal Function | Gene Name (Symbol) | Gene Function | Log2-Fold Change | P adj | DE |
|---|---|---|---|---|---|
| Right colon mucosa | |||||
| Inflammation-related genes | C-X-C Motif Chemokine Ligand 1 (CXCL1) | Chemotaxis for neutrophils and inflammation, and affects endothelial cells in an autocrine fashion | 1.392443 | 0.014487 | Up |
| C-C Motif Chemokine Ligand 21 (CCL21) | Inhibits hemopoiesis and stimulates chemotaxis | −1.61646 | 0.018378 | Down | |
| Ion-binding or carrier-related genes | S100 Calcium Binding Protein P (S100P) | Binds calcium ions | 1.030017 | 0.000677 | Up |
| Solute Carrier Family 6 Member 19 (SLC6A19) | Apical membrane epithelial transporter mediating absorption of neutral amino acids (e.g., leucine) in intestine. Defects in SLC6A19 are a cause of Hartnup disease. | −1.68011 | 0.018721 | Down | |
| Left colon mucosa | |||||
| Inflammation-related genes | Prostaglandin-Endoperoxide Synthase 2 (PTGS2) | Mediator of inflammation and/or prostanoid signaling; induction by cytokines and mitogens | 1.193292 | 0.00539 | Up |
| Cellular Communication Network Factor 1 (CYR61) | Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion | 1.367793 | 0.018244 | Up | |
| Activating Transcription Factor 3 (ATF3) | Binds the cAMP response element (CRE), a sequence which is present in many viral and cellular promoters. ATF3 represses transcription from viral and cellular promoters with ATF sites | 1.234673 | 0.014649 | Up | |
| C-X-C Motif Chemokine Ligand 8 (CXCL8) | Major mediator of the inflammatory response, encoding interleukin-8, a chemotactic factor that attracts neutrophils, basophils, and T-cells, and activates neutrophils | 1.426137 | 0.043853 | Up | |
| Genes related to early growth and cellular differentiation | Early Growth Response 1 (EGR1) | Transcriptional regulator that activates the transcription of target genes whose products are required for mitogenesis and differentiation. | 1.717686 | 0.000809 | Up |
| Early Growth Response 2 (EGR2) | DNA-binding transcription factor activating 2 specific DNA sites located in the promoter region of HOXA4 | 1.504452 | 0.008922 | Up | |
| Early Growth Response 3 (EGR3) | Transcription factor involved in muscle spindle development | 1.912399 | 0.000297 | Up | |
IBS, irritable bowel syndrome; DE, differential expressions; up, upregulated; down, downregulated.