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. 2021 May 7;23(11):1875–1887. doi: 10.1002/ejhf.2195

Figure 4.

EJHF-2195-FIG-0004-c

Enrichment analysis based on Reactome pathways. (A) Network of enriched terms. Graphical representation of pathways significantly enriched based on the predicted proteases and proteins representing the urinary peptides. Networks are coloured based on cluster ID, the thickness of the edge represents the similarity score. The most significant term from each cluster was selected as label and for those terms, P‐value corrected using Banjamini–Hochberg (BH) procedure is given. Among the most prominent findings, significant enrichment for pathways related to collagen turnover (highlighted in blue) and immune response (highlighted in orange) was observed. (B) Parental proteins and predicted proteases annotated to the most significant terms. A1BG, alpha‐1B‐glycoprotein; ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4; AHSG, alpha‐2‐HS‐glycoprotein; APOA1, apolipoprotein A‐I; B2M, beta‐2‐microglobulin form pI 5.3; C3, complement C3; CAPN1, calpain‐1 catalytic subunit; CAPN2, calpain‐2 catalytic subunit; CD99, CD99 antigen; CDH1, cadherin 1; CFB, complement factor B; CHGB, secretogranin‐1; CLU, clusterin; COL11A1, collagen alpha‐1(XI) chain; COL11A2, collagen alpha‐2(XI) chain; COL14A1, collagen alpha‐1(XIV) chain; COL15A1, collagen alpha‐1(XV) chain; COL16A1, collagen alpha‐1(XVI) chain; COL17A1, collagen alpha‐1(XVII) chain; COL18A1, collagen alpha‐1(XVIII) chain; COL19A1, collagen alpha‐1(XIX) chain; COL1A1, collagen alpha‐1(I) chain; COL1A2, collagen alpha‐2(I) chain; COL22A1, collagen alpha‐1(XXII) chain; COL23A1, collagen alpha‐1(XXIII) chain; COL25A1, collagen alpha‐1(XXV) chain; COL28A1, collagen alpha‐1(XXVIII) chain; COL2A1, collagen alpha‐1(II) chain; COL3A1, collagen alpha‐1(III) chain; COL4A1, collagen alpha‐1(IV) chain; COL4A2, collagen alpha‐2(IV) chain; COL4A3, collagen alpha‐3(IV) chain; COL4A4, collagen alpha‐4(IV) chain; COL4A5, collagen alpha‐5(IV) chain; COL4A6, collagen alpha‐6(IV) chain; COL5A1, collagen alpha‐1(V) chain; COL5A2, collagen alpha‐2(V) chain; COL5A3, collagen alpha‐3(V) chain; COL6A1, collagen alpha‐1(VI) chain; COL6A2, collagen alpha‐2(VI) chain; COL7A1, collagen alpha‐1(VII) chain; COL8A1, collagen alpha‐1(VIII) chain; COL8A2, collagen alpha‐2(VIII) chain; COL9A2, collagen alpha‐2(IX) chain; COL9A3, collagen alpha‐3(IX) chain; CTSB, cathepsin B; CTSK, cathepsin K; CTSL, cathepsin L1; CTSS, cathepsin S; EFNA1, ephrin‐A1; F2, thrombin light chain; FGA, fibrinogen alpha chain; FGB, fibrinogen beta chain; GSN, gelsolin; H2BC12, histone H2B type 1‐K; HBA1, haemoglobin subunit alpha; HBB, haemoglobin subunit beta; HSPB1, heat shock protein beta‐1; INS, insulin; ITIH4, 35 kDa inter‐alpha‐trypsin inhibitor heavy chain H4; LMAN2, vesicular integral‐membrane protein VIP36; MAN1A1, mannosyl‐oligosaccharide 1;2‐alpha‐mannosidase IA; MASP2, mannan‐binding lectin serine protease 2; MMP1, interstitial collagenase; MMP12, macrophage metalloelastase; MMP13, collagenase 3; MMP14, matrix metalloproteinase‐14; MMP2, 72 kDa type IV collagenase; MMP25, matrix metalloproteinase‐25; MMP3, stromelysin‐1; MMP7, matrilysin; MMP8, neutrophil collagenase; MMP9, matrix metalloproteinase‐9; ORM1, alpha‐1‐acid glycoprotein 1; PCDH7, protocadherin‐7; PGRMC1, membrane‐associated progesterone receptor component 1; PIGR, polymeric immunoglobulin receptor; PLG, plasminogen; PPP3CA, serine/threonine‐protein phosphatase; S100A8, protein S100‐A8; S100A9, protein S100‐A9; SERPINA1, alpha‐1‐antitrypsin; SPP1, osteopontin; TMSB4X, thymosin beta‐4; TTR, transthyretin; TUBB3, tubulin beta‐3 chain; UMOD, uromodulin; VGF, neurosecretory protein VGF. *In silico predicted proteases.