TABLE 3.
Characteristics of All Patients Who Have Undergone Transplantation
| At Transplant | SBRT (n = 27) | TACE (n = 32) | HIFU (n = 28) | P Value |
|---|---|---|---|---|
| MELD at transplant | 12 (8‐33) | 10 (8‐12) | 12 (11‐15) | 0.001 |
| AFP at transplant (ng/mL) | 6 (3‐339) | 7.5 (1‐1,286) | 12 (2‐21,984) | 0.177 |
| Radiological tumor number | 1.0 (0‐3) | 1.0 (0‐3) | 1.0 (0‐3) | 0.167 |
| Radiological tumor size (cm) | 2.0 (0‐5.7) | 1.6 (0‐5.8) | 2.1 (0‐4.3) | 0.214 |
| Radiological within Milan (n, %) | 25 (92.6) | 29 (90.6) | 26 (92.9) | 0.941 |
| Time on waiting list (days) | 421 (89‐944) | 255.5 (21‐1,280) | 241 (1‐1,909) | 0.21 |
| Perioperative outcomes | ||||
| Hospital mortality (n, %) | 1 (3.8) | 0 (0) | 1 (3.6) | 0.527 |
| Postoperative complication ≥Clavien Grade 3a* (n, %) | 7 (26.9) | 4 (12.5) | 8 (28.6) | 0.253 |
| Overall complication rate (n, %) | 18 (69.2) | 16 (50.0) | 19 (67.9) | 0.232 |
| Vascular thrombosis (n, %) | 1 (3.7) | 0 (0) | 0 (0) | 0.106 |
| Early biliary leak/ stricture (n, %) | 0 (0) | 0 (0) | 0 (0) | — |
| Blood loss (L) | 3.0 (0.75‐15.0) | 3.0 (0.5‐11.7) | 3.9 (0.7‐20.0) | 0.806 |
| Intraoperative packed cell transfusion (units) | 6.0 (0‐21) | 5.0 (0‐29) | 4.5 (0‐31) | 0.91 |
| Intraoperative FFP transfusion (units) | 5.0 (0‐21) | 4.0 (0‐17) | 6.0 (0‐17) | 0.554 |
| Intraoperative platelet transfusion (units) | 6.0 (0‐28) | 4.0 (0‐16) | 8.0 (0‐24) | 0.313 |
| ICU stay (days) | 3.0 (2‐52) | 3.0 (2‐7) | 3.0 (2‐32) | 0.611 |
| Hospital stay (days) | 16.0 (10‐174) | 15.0 (10‐69) | 15.0 (8‐132) | 0.79 |
| Explant pathological analysis | ||||
| Pathological tumor number | 1.0 (0‐multiple) | 2.0 (0‐multiple) | 1.0 (0‐multiple) | 0.666 |
| Pathological tumor size (cm) | 2.0 (0.8‐4.5) | 2.5 (0.3‐6.3) | 2.5 (0.3‐6.3) | 0.045 |
| Pathological complete necrosis (n, %) | 13 (48.1) | 8 (25.0) | 5 (17.9) | 0.037 |
| Tumor differentiation (n, %) † | 0.361 | |||
| Well differentiated | 2 (7.7) | 2 (6.3) | 3 (10.7) | |
| Moderately differentiated | 12 (46.2) | 21 (65.6) | 19 (67.9) | |
| Poorly differentiated | 3 (11.5) | 1 (3.1) | 1 (3.6) | |
| Vascular invasion (n, %) † | ||||
| Microvascular | 6 (22.2) | 8 (25.0) | 7 (25.0) | 0.079 |
| Macrovascular | 1 (3.7) | 0 (0) | 1 (3.6) | 0.529 |
| Pathological within Milan (n, %) | 22 (81.5) | 24 (75.0) | 21 (75.0) | 0.442 |
Variables were presented as median (range) or number (percentage).
*
Clavien‐Dindo classification.
†
Pathological details were not available in patients who had complete necrosis.
Abbreviations: FFP, fresh frozen plasma; ICU, intensive care unit.