TABLE 2.
Characteristics of enrolled patients reported in the SUSTAIN 7 and AWARD‐11 trials
| Trial name | SUSTAIN 7 | AWARD‐11 | |||||
|---|---|---|---|---|---|---|---|
| Treatment | Semaglutide 1.0 mg (n = 300) | Dulaglutide 1.5 mg (n = 299) | Pooled treatment arms (semaglutide 1.0 mg and dulaglutide 1.5 mg) (n = 599) | Dulaglutide 3.0 mg (n = 616) | Dulaglutide 4.5 mg (n = 614) | Dulaglutide 1.5 mg (n = 612) | Pooled treatment arms (dulaglutide 3.0 mg, 4.5 mg and 1.5 mg) (n = 1842) |
| Mean age (SD), y | 55 (10.6) | 56 (10.6) | 55.6 (10.6) | 56.9 (10.2) | 56.6 (10.2) | 57.8 (9.7) | 57.1 (10.0) |
| Mean baseline HbA1c (SD), % | 8.2 (0.9) | 8.2 (0.9) | 8.2 (0.9) | 8.6 (1.0) | 8.6 (0.9) | 8.6 (0.9) | 8.6 (1.0) |
| Fasting glucose a (SD), mg/dL | 177.1 (46.5) | 172.5 (41.2) | 174.8 (44.0) | 184 (54.4) | 183.4 (48.0) | 185 (52.0) | 184.1 (51.5) |
| Mean body weight (SD), kg | 95.5 (20.9) | 93.4 (21.8) | 94.5 (21.4) | 96.3 (20.1) | 95.4 (20.6) | 95.5 (20.2) | 95.7 (20.3) |
| Mean BMI (SD), kg/m2 | 33.6 (6.5) | 33.1 (6.6) | 33.3 (6.5) | 34.3 (6.2) | 34.0 (6.2) | 34.4 (6.4) | 34.2 (6.3) |
| Mean T2D duration (SD), y | 7.3 (5.7) | 7.6 (5.6) | 7.5 (5.7) | 7.6 (5.5) | 7.7 (5.8) | 7.6 (5.8) | 7.6 (5.7) |
| Female, n (%) | 138 (46.0) | 128 (43.0) | 268 (44.4) | 288 (46.8) | 296 (48.2) | 314 (51.3) | 898 (48.8) |
| Race, n (%) | |||||||
| White | 243 (81.0) | 220 (74.0) | 463 (77.3) | 521 (84.6) | 530 (86.3) | 529 (86.4) | 1580 (85.8) |
| Black or African American | 18 (6.0) | 18 (6.0) | 36 (6.0) | 31 (5.0) | 23 (3.7) | 28 (4.6) | 82 (4.5) |
| Asian | 38 (13.0) | 55 (18.0) | 93 (15.5) | 18 (2.9) | 14 (2.3) | 13 (2.1) | 45 (2.4) |
| Other/multiple | 1 (<1) | 6 (2.0) | 7 (1.17) | 46 (7.5) | 47 (7.7) | 42 (6.9) | 135 (7.3) |
| Mean eGFR (SD), mL/min/1.73m2 | 97 (17.2) | 95 (18.0) | 96 (17.6) | 93.3 (17.8) | 93.7 (18.3) | 93.4 (18.2) | 93.5 (18.1) |
| Mean SBP (SD), mmHg | 133 (14.5) | 132 (13.6) | 132.6 (14.1) | 131.1 (14.1) | 132.1 (14.0) | 132.1 (14.2) | 131.8 (14.1) |
| Mean DBP (SD), mmHg | 82 (9.1) | 80 (8.7) | 80.8 (8.9) | 78.4 (8.7) | 79 (9.0) | 78.8 (9.3) | 78.7 (9.0) |
| Mean HR (SD), bpm | 76 (10.6) | 75 (10.5) | 75.5 (10.6) | 75.3 (9.5) | 75.5 (10.3) | 75.6 (10.1) | 75.5 (10.0) |
Abbreviations: BMI, body mass index; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FPG, fasting plasma glucose; FSG, fasting serum glucose; HR, heart rate; SBP, systolic blood pressure; SD, standard deviation; T2D, type 2 diabetes.
a
FPG recorded in SUSTAIN 7 and FSG recorded in AWARD‐11.