FIGURE 5.

Antibody responses and proliferation responses in vaccinated and unvaccinated goats. The PPRV‐specific immune responses were measured for all animals in terms of (a) the PPRV‐specific antibody response and (b, c) the PPRV‐specific T‐cell response. Depletion of CD8⁺ cells, or mock depletion, occurred before challenge, which was at 28 dpv (arrow). (a) Levels of anti‐PPRV antibody were determined for all animals using competition ELISA (cELISA); for this assay, a reduction in binding of the specific monoclonal antibody indicates the presence of competing anti‐PPRV antibodies. (b, c) Proliferation of purified leucocytes in response to stimulation with (b) heat‐inactivated (HI) virus or (c) an inactivated preparation of virus protein (virus antigen). Proliferation is shown as the cumulative stimulation index (SI) for each group of animals, normalized to the number of animals in each group