Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 15;11(1):2101769. doi: 10.1080/2162402X.2022.2101769

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 5. — Monounsaturated fatty acids (OA and POA) protect tumor cells from radiation-induced ferroptosis and lead to radiation resistance. However, RT-induced lipid peroxidation could not be mitigated by saturated fatty acids (PA and SA). (a) C11-BODIPY staining analyzed by flow cytometry in KYSE70 cells following NC (DMSO), OA (0.1 mM), RT (6 Gy), or RT/OA. (b) C11-BODIPY staining analyzed by flow cytometry in KYSE410 cells following NC (DMSO), OA (0.1 mM), RT (6 Gy), or RT/OA. (c) C11-BODIPY staining analyzed by flow cytometry in KYSE70 cells following NC (DMSO), POA (0.1 mM), RT (6 Gy), or RT/POA. (d) C11-BODIPY staining analyzed by flow cytometry in KYSE410 cells following NC (DMSO), POA (0.1 mM), RT (6 Gy), or RT/POA. (e) C11-BODIPY staining analyzed by flow cytometry in KYSE70 cells following NC (DMSO), PA (0.1 mM), RT (6 Gy), or RT/PA. (f) C11-BODIPY staining analyzed by flow cytometry in KYSE410 cells following NC (DMSO), PA (0.1 mM), RT (6 Gy), or RT/PA. (g) C11-BODIPY staining analyzed by flow cytometry in KYSE70 cells following NC (DMSO), SA (0.1 mM), RT (6 Gy), or RT/SA. (h) C11-BODIPY staining analyzed by flow cytometry in KYSE410 cells following NC (DMSO), SA (0.1 mM), RT (6 Gy), or RT/SA. (i-j) Colony formation assay was performed in tumor cells following RT (0, 2, 4, 6, 8, 10, and 12 Gy), or RT/OA treatment (0.1 mM). (k-l) Colony formation assay was performed in cancer cells following RT (0, 2, 4, 6, 8, 10, and 12 Gy), or RT/POA treatment (0.1 mM). Data are expressed as means ± SD (n = 3), p > .05; *p ˂ 0.05; **p ˂ 0.01; ***p ˂ 0.001; ****p ˂ 0.0001.

Abbreviations: NC, normal control; OA, oleic acid; PA, palmitic acid; POA, palmitoleic acid; RT, radiation therapy; SA, stearic acid; SCD1, stearoyl-coa desaturase; n.s, non-significant.