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. 2022 Jul 15;44(1):1169–1181. doi: 10.1080/0886022X.2022.2098764

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Molecular docking showed the potential binding of disulfiram to the TIR domain. (a) Western blot analysis of TLR4 expression in vivo. (b) Western blot analysis of TLR4 expression in vitro. (c) Homology modeling of the 3D structure of the TIR domain. (d) A docking pose of disulfiram in the binding pocket close to the BB loop. Protein expression was quantified by densitometric analysis. Each bar represents the mean ± SEM of three independent experiments. **P < 0.01, ***P < 0.001 vs. control. ns, no significance.