FIGURE 4.

Adeno‐associated virus (AAV) transduction and expression of phenylalanine hydroxylase gene (PAH) was well tolerated in all animals. A, There were no significant variations in body weights over the course of the study within genotypes regardless of vector dose administered. Serum liver enzymes indicated only minor effects on hepatocytes, with Anc80‐int‐coPAH being associated with a minor elevation in, B, ALT at the high dose relative to the untreated Pah^enu2 control mice, and no effects of either Anc80 construct on, C, AST, or D, ALP at week 12