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. 2021 Aug 24;11(2):278–284. doi: 10.1002/cpdd.1009

Table 2.

Mean (SD) Pharmacokinetic Parameters for Vonoprazan Following a Single 20‐mg Oral Dose Under Fed and Fasted Conditions

Fed (n = 24) Fasted (n = 24)
Cmax, ng/mL 18.9 (5.12) 18.2 (5.76)
AUC0‐24, ng • h/mL 181.5 (52.84) 160.8 (49.50)
AUC0‐∞, ng • h/mL 206.1 (66.62) 179.3 (58.37)
tmax, h, median (min, max) 4.0 (1.98, 6.02) 2.0 (0.75, 4.00)
t1/2, h 6.9 (1.21) 6.9 (1.45)

AUC0‐∞, area under the plasma concentration–time curve from time 0 extrapolated to infinity; AUC0‐24, area under the plasma concentration–time curve from time 0 to 24 hours; Cmax, maximum observed concentration; max, maximum; min, minimum; SD, standard deviation; tmax, time at which the maximum observed concentration occurred; t1/2, terminal elimination half‐life.