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. 2021 Aug 24;11(2):278–284. doi: 10.1002/cpdd.1009

Table 3.

Bioavailability of Vonoprazan Following a Single 20‐mg Oral Dose Administered Under Fed and Fasted Conditions (N = 24)

Least‐Squares Means
Fed Fasted Fed/Fasted Ratio 90% CI
Cmax, ng/mL 18.2 17.3 1.05 0.98‐1.12
AUC0‐24, ng • h/mL 174.3 153.8 1.13 1.09‐1.18
AUC0‐∞ (ng • h/mL) 196.2 170.6 1.15 1.11‐1.19

AUC0‐∞, area under the plasma concentration–time curve from time 0 extrapolated to infinity; AUC0‐24, area under the plasma concentration–time curve from time 0 to 24 hours; CI, confidence interval; Cmax, maximum observed concentration.