TABLE 2.
Parameter estimates from the final model
| Parameter | Description | Estimate | Bootstrap | ||
|---|---|---|---|---|---|
| (% RSE) | Median | 2.5–97.5 percentile | |||
| Structural model | |||||
| V/F, L | Typical value of apparent V | 322 | (31) | 292 | (199–572) |
| CL/F, L/h | Typical value of apparent CL | 0.033 | (23) | 0.034 | (0.011–0.043) |
| C0, ng/mL | Typical value of basal concentration | 17.2 | (6) | 17.1 | (15.4–19.2) |
| Ka, /h | Absorption rate constant | 0.323 | (fixed) | 0.323 | (fixed) |
| Statistical model | |||||
| ωCL/F, %CV | BSV of apparent CL | 93.7 | (42) | 89.5 | (63.5–162) |
| ωC0, %CV | BSV of C0 | 34.2 | (32) | 35.2 | (23.6–44.7) |
| Residual, %CV | Residual variability | 38.1 | (19) | 36.7 | (29.8–43.5) |
Note: Allometric scaling with exponents of 0.75 and 1 on apparent clearance (CL/F) and volume of distribution (V/F) were added a priori, standardised to 24 kg. BSV, between subject variability; CV%, coefficient of variation as a percentage; C0, basal 25(OH)D concentration; RSE, relative standard error.