Table 1.
Patients’ characteristics at baseline and weighted characteristics after IPTW
| Patients’ characteristics n = 39,992 | Weighted populations | |||||||
|---|---|---|---|---|---|---|---|---|
|
DOAC n = 8,789 |
VKA n = 31,200 |
DOAC | VKA | Standardized diff. | ||||
| Mean | SE | Mean | SE | Mean | Mean | Before | After | |
| Age (age when first started treatment) | 74.42 | 0.12 | 75.36 | 0.05 | 75.33 | 75.17 | 0.09 | −0.015 |
| N | % | N | % | % | % | |||
| Sex (female) | 4,112 | 46.8 | 15,054 | 48.3 | 48.3 | 48.0 | 0.029 | −0.007 |
| Country | ||||||||
| Africa | 60 | 07 | 160 | 0.5 | 0.6 | 0.5 | −0.022 | −0.015 |
| America | 75 | 0.8 | 213 | 0.7 | 0.8 | 0.7 | −0.020 | −0.017 |
| Spain | 7,755 | 88.2 | 28,488 | 91.3 | 88.5 | 91.2 | 0.102 | 0.089 |
| Europe | 739 | 8.4 | 1,699 | 5.4 | 8.2 | 5.5 | −0.117 | −0.107 |
| Other | 160 | 1.8 | 640 | 2.1 | 1.8 | 2.1 | 0.017 | 0.020 |
| Vulnerability | ||||||||
| No risk | 8,087 | 92.0 | 28,655 | 91.8 | 92 | 91.8 | −0.006 | −0.005 |
| Unemployed | 169 | 1.9 | 560 | 1.8 | 1.7 | 1.9 | −0.009 | 0.014 |
| Irregular foreigner | 2 | 0,02 | 14 | 0.04 | 0 | 0 | 0.012 | 0.013 |
| Without resources | 218 | 2,5 | 772 | 2.5 | 2.5 | 2.5 | 0.000 | −0.004 |
| Undefined | 4 | 0,1 | 11 | 0.04 | 0 | 0 | −0.005 | −0.006 |
| Missing | 309 | 3,5 | 1,188 | 3.8 | 3.7 | 3.7 | 0.016 | 0.000 |
| Income | ||||||||
| < 18,000 | 6,294 | 71,6 | 23,996 | 76.9 | 70.5 | 76.8 | 0.121 | 0.098 |
| 18,000–100,000 | 1,836 | 20,9 | 4,722 | 15.1 | 20 | 15.3 | −0.150 | −0.122 |
| > 100,000 | 75 | 0,9 | 63 | 0.2 | 0.8 | 0.2 | −0.090 | −0.078 |
| Without resources | 309 | 3,5 | 1,211 | 3.9 | 3.6 | 3.9 | 0.019 | 0.016 |
| Unknown | 275 | 3,1 | 1,208 | 3.9 | 3.2 | 3.9 | 0.040 | 0.036 |
| Cancer risk factors | ||||||||
| Smoking | 899 | 10,2 | 3,395 | 10.9 | 10.7 | 10.7 | 0.021 | 0.003 |
| Gastritis | 530 | 6,0 | 1,867 | 6.0 | 6.1 | 6 | −0.002 | −0.002 |
| Intestinal polyps | 146 | 1,7 | 500 | 1.6 | 1.6 | 1.6 | −0.005 | −0.002 |
| COPD | 439 | 5,0 | 1,715 | 5.5 | 5.4 | 5.4 | 0.023 | 0.000 |
| Inflammatory bowel disease | 79 | 0,9 | 191 | 0.6 | 0.7 | 0.7 | −0.032 | 0.002 |
| Alcohol use | 178 | 2,0 | 678 | 2.2 | 2.2 | 2.1 | 0.004 | −0.003 |
| Comorbidities | ||||||||
| Rheumatologic diseases | 193 | 2.2 | 729 | 2.3 | 2.3 | 2.3 | 0.009 | −0.002 |
| Previous organ transplant | 18 | 0.2 | 175 | 0.6 | 0.5 | 0.5 | 0.058 | 0.004 |
| Coronary heart disease | 1,471 | 18.5 | 5,781 | 18.1 | 18.2 | 17.9 | 0.047 | −0.007 |
| VTE‐PE | 458 | 5.2 | 2,330 | 7.5 | 7.0 | 7.0 | 0.093 | −0.002 |
| Gastrointestinal bleeding | 355 | 4.0 | 1,284 | 4.1 | 4.1 | 4.1 | 0.004 | −0.005 |
| Heart failure | 1,382 | 15.7 | 5,756 | 18.5 | 18.2 | 17.9 | 0.072 | −0.009 |
| Hypertension | 6,775 | 77.1 | 25,090 | 80.4 | 79.9 | 79.7 | 0.082 | −0.005 |
| Diabetes | 2,756 | 31.4 | 11,188 | 35.9 | 35.1 | 34.9 | 0.095 | −0.004 |
| Liver disease | 615 | 7.0 | 2,274 | 7.3 | 7.2 | 7.2 | 0.011 | 0.000 |
| Renal disease | 839 | 9.7 | 4,315 | 13.8 | 12.9 | 12.9 | 0.134 | 0.001 |
| Previous stroke or TIA | 1,912 | 21.7 | 6,255 | 20.1 | 20.7 | 20.5 | −0.042 | −0.006 |
| Dementia | 717 | 8.2 | 2,129 | 6.8 | 7.2 | 7.1 | 0.031 | −0.005 |
| Depression | 1,194 | 13.6 | 4,285 | 13.7 | 13.8 | 13.7 | −0.051 | −0.002 |
COPD, chronic obstructive pulmonary disease; DOAC, direct oral anticoagulant; IPTW, inverse probability treatment‐weighting; TIA, transient ischemic attack; VKA, vitamin K antagonist; VTE‐PE, venous thromboembolism or pulmonary embolism.