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. 2021 May 27;40(20):4362–4375. doi: 10.1002/sim.9034

FIGURE A2.

SIM-9034-FIG-0004-c

Venn diagram for candidate characteristics to include in the prognostic model (stage 1). Light blue indicates all 31 characteristics after deleting the correlated variables and those with a big amount of missing values (>50%). Light green indicates the variables selected by LASSO and purple indicates the variables included in prespecified model. EDSS, expanded disability status scale; FSS, functional system score; LASSO, least absolute shrinkage and selection operator; SF‐36 MCS, short form‐36 mental component summary; SF‐36 PCS, short form‐36 physical component summary; VAS, visual analog scale; VFT, visual function test [Colour figure can be viewed at wileyonlinelibrary.com]