FIG. 1.

Fold changes of plasma levels of NR (nicotinamide riboside) metabolites and purine nucleosides after 4‐month treatment with NR. (A) Fold changes of four metabolites are given for individual patients: N1‐methyl‐2‐pyridone‐5‐carboxamide (first bar, black), N1‐methyl‐4‐pyridone‐5‐carboxamide (second bar, white), N1‐methylnicotinamide (third bar, dark gray), and nicotinamide (fourth bar, light gray). (B) Fold changes of adenosine (first bar, black), guanosine (second bar, white), and inosine (third bar, dark gray) are given for every single patient.