TABLE 3.
Diagnostic test results
| PRO‐C3 | ADAPT | Forns | |
|---|---|---|---|
| Total cohort | |||
| Prevalence, n (%) | 72 (17) | 72 (17) | 71 (17) |
| AUROC (95% CI) | 0.85 (0.79‐0.90) | 0.88 (0.83‐0.93) | 0.83 (0.78‐0.89) |
| Cut‐off | 15.6 | 6.3287 | 6.9 |
| Correctly classifies, n (%) | 318 (75) | 338 (79) | 358 (85) |
| TP/FP/FN/TN | 58/94/14/260 | 62/78/10/276 | 48/39/24/310 |
| Sensitivity (%) | 81 (70‐89) | 86 (76‐93) | 67 (55‐77) |
| Specificity (%) | 73 (69‐78) | 78 (73‐82) | 89 (85‐92) |
| PPV (%) | 38 (30‐46) | 44(36‐53) | 55 (44‐66) |
| NPV (%) | 95 (92‐97) | 97 (94‐98) | 93 (90‐95) |
| Pre‐test odds | 0.20 | 0.20 | 0.21 |
| LR (+) | 3.03 (2.47‐3.73) | 3.91 (3.15‐4.85) | 5.97 (4.26‐8.36) |
| LR (−) | 0.27 (0.17‐0.43) | 0.18 (0.1‐0.32) | 0.38 (0.27‐0.52) |
| Test cohort | |||
| Prevalence n (%) | 45 (21) | 45 (21) | 55 (21) |
| AUROC (95% CI) | 0.86 (0.79‐0.92) | 0.91 (0.86‐0.96) | 0.83 (0.76‐0.90) |
| Cutoff | 15.6 | 6.3287 | 6.9 |
| Correctly classifies n (%) | 164 (77) | 168 (79) | 180 (85) |
| TP/FP/FN/TN | 36/40/9/128 | 39/39/6/129 | 30/17/15/150 |
| Sensitivity (%) | 80 (65‐99) | 87 (73‐95) | 67 (51‐80) |
| Specificity (%) | 76 (69‐82) | 77 (70‐83) | 90 (84‐94) |
| PPV (%) | 47 (36‐59) | 50 (39‐62) | 64 (49‐77) |
| NPV (%) | 93 (98‐97) | 96 (91‐98) | 91 (85‐95) |
| Pre‐test odds | 0.27 | 0.27 | 0.27 |
| LR (+) | 3.36 (2.47‐4.57) | 3.73 (2.77‐5.03) | 6.55 (3.99‐10.8) |
| LR (−) | 0.26 (0.15‐0.47) | 0.17 (0.08‐0.37) | 0.37 (0.25‐0.56) |
| Validation cohort | |||
| Prevalence n (%) | 27 (13) | 27 (13) | 27 (13) |
| AUROC (95% CI) | 0.83 (0.75‐0.92) | 0.85 (0.75‐0.94) | 0.84 (0.75‐0.92) |
| Cutoff | 15.6 | 6.3287 | 6.9 |
| Correctly classifies, n (%) | 154 (72) | 170 (80) | 178 (85) |
| TP/FP/FN/TN | 22/54/5/132 | 23/39/4/147 | 18/22/9/160 |
| Sensitivity (%) | 82 (62‐94) | 85 (66‐96) | 67 (46‐84) |
| Specificity (%) | 71 (64‐77) | 79 (73‐85) | 88 (82‐92) |
| PPV (%) | 29 (19‐41) | 37 (25‐50) | 45 (29‐62) |
| NPV (%) | 96 (92‐99) | 97 (93‐99) | 85 (90‐98) |
| Pre‐test odds | 0.15 | 0.15 | 0.15 |
| LR (+) | 2.81 (2.1‐3.74) | 4.06 (2.95‐5.6) | 5.12 (3.43‐8.86) |
| LR (−) | 0.26 (0.12‐0.58) | 0.19 (0.08‐0.47) | 0.38 (0.22‐0.65) |
Abbreviations: AUROC, area under the receiver operating characteristics curve; FN, false negative; FP, false positive; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; TN, true negative; TP, true positive.