TABLE 2.
Cox Regression Analysis of Factors Associated with Time to Post‐Stroke Epilepsy Following Acute Ischemic Stroke
| Univariable | Multivariable | |||
|---|---|---|---|---|
| HR (95% CI) | p value | aHR (95% CI) | p value | |
| Age | 0.99 (0.99–1.01) | 0.096 | ||
| Sex (male) | 0.86 (0.66–1.11) | 0.266 | ||
| NIHSS at admission | ||||
| 0–3 | 0.41 (0.31–0.55) | <0.001 | 0.75 (0.52–1.09) | 0.136 |
| 4–10 | 0.79 (0.59–1.05) | 0.108 | ||
| ≥11 | 3.62 (2.79–4.69) | <0.001 | 2.33 (1.69–3.21) | <0.001 |
| Stroke etiology | ||||
| Large‐artery atherosclerosis | 2.07 (1.52–2.64) | <0.001 | 1.51 (1.13–2.01) | 0.004 |
| Small‐vessel occlusion | 0.37 (0.24–0.57) | <0.001 | 0.92 (0.57–1.46) | 0.728 |
| Cardioembolic | 0.98 (0.73–1.30) | 0.901 | ||
| Stroke location | ||||
| Middle cerebral artery | 2.26 (1.62–3.15) | <0.001 | 1.35 (0.95–1.92) | 0.087 |
| Anterior cerebral artery | 0.98 (0.50–1.91) | 0.957 | ||
| Posterior cerebral artery | 1.15 (0.86–1.54) | 0.330 | ||
| Cortical involvement | 2.75 (2.07–3.66) | <0.001 | 2.07 (1.54–2.80) | <0.001 |
| ASS | 5.87 (4.11–8.38) | <0.001 | 4.18 (2.90–6.02) | <0.001 |
| Reperfusion treatment | 1.85 (1.41–2.40) | <0.001 | 1.05 (0.78–1.40) | 0.727 |
HR = hazard ratio; aHR = adjusted hazard ratio; ASS = acute symptomatic seizure; CI = confidence interval; NIHSS = National Institutes of Health Stroke Scale.