Table 1. Statistically different taxa emerged from the application of a multivariable linear regression model.
To test the association between microbial taxa healthy abundances versus Lichen diagnosis, the software MaAsLin2 has been used at different taxonomic level for swab and sub-epidermal layers (swab, deep epidermis, dermis, hypodermis).
| Layer | taxa level | feature | coeff | stderr | N | pval |
|---|---|---|---|---|---|---|
| dermis | family | Microbacteriaceae | -1.03 | 0.2 | 8 | 0.002 |
| swab | phylum | Cyanobacteria | 0.75 | 0.27 | 26 | 0.01 |
| swab | phylum | Euryarchaeota | 0.21 | 0.1 | 26 | 0.053 |
| swab | phylum | Firmicutes | -0.56 | 0.27 | 26 | 0.051 |
| swab | family | Pasteurellaceae | -1.02 | 0.39 | 26 | 0.014 |
| swab | family | Unassigned_Lactobacillales | -0.92 | 0.29 | 26 | 0.004 |
| swab | family | Neisseriaceae | -0.73 | 0.28 | 26 | 0.017 |
| swab | family | Other_Firmicutes | -0.63 | 0.24 | 26 | 0.013 |
| swab | family | Leptotrichiaceae | -0.61 | 0.25 | 26 | 0.021 |
| swab | family | Clostridiaceae | 0.1 | 0.04 | 26 | 0.033 |
| swab | family | Cystobacteraceae | 0.1 | 0.04 | 26 | 0.034 |
| swab | family | Chlamydomonadaceae | 0.1 | 0.04 | 26 | 0.035 |
| swab | family | Unassigned_Rhodospirillales | 0.1 | 0.04 | 26 | 0.037 |
| swab | family | Unassigned_Pseudomonadales | 0.11 | 0.05 | 26 | 0.038 |
| swab | family | Erythrobacteraceae | 0.11 | 0.05 | 26 | 0.039 |
| swab | family | Phormidiaceae | 0.12 | 0.06 | 26 | 0.041 |
| swab | family | Unassigned_Rickettsiales | 0.12 | 0.06 | 26 | 0.044 |
| swab | family | Pseudanabaenaceae | 0.12 | 0.06 | 26 | 0.047 |
| swab | family | Aeromonadaceae | 0.13 | 0.06 | 26 | 0.039 |
| swab | family | Unassigned_Chroococcales | 0.14 | 0.06 | 26 | 0.042 |
| swab | family | Rhodospirillaceae | 0.32 | 0.12 | 26 | 0.018 |
| swab | family | Xanthomonadaceae | 0.38 | 0.16 | 26 | 0.023 |
| swab | family | Oxalobacteraceae | 0.4 | 0.17 | 26 | 0.026 |
| swab | family | Bradyrhizobiaceae | 0.49 | 0.23 | 26 | 0.047 |
| swab | family | Unassigned_Burkholderiales | 0.53 | 0.22 | 26 | 0.023 |
| swab | family | Caulobacteraceae | 0.6 | 0.24 | 26 | 0.018 |
| swab | family | Other_Cyanobacteria | 0.86 | 0.31 | 26 | 0.01 |
| swab | genus | Unclassified_Pasteurellaceae | -1.02 | 0.39 | 26 | 0.014 |
| swab | genus | Unclassified_Neisseriaceae | -0.67 | 0.29 | 26 | 0.031 |
| swab | genus | Unclassified_Leptotrichiaceae | -0.56 | 0.24 | 26 | 0.03 |
| swab | genus | Verrucomicrobium | 0.09 | 0.04 | 26 | 0.033 |
| swab | genus | Haloferula | 0.09 | 0.04 | 26 | 0.033 |
| swab | genus | Clostridium | 0.1 | 0.04 | 26 | 0.033 |
| swab | genus | Unclassified_Cystobacteraceae | 0.1 | 0.04 | 26 | 0.034 |
| swab | genus | Unclassified_Erythrobacteraceae | 0.1 | 0.04 | 26 | 0.034 |
| swab | genus | Novosphingobium | 0.1 | 0.04 | 26 | 0.034 |
| swab | genus | Unclassified_Pseudanabaenaceae | 0.1 | 0.04 | 26 | 0.036 |
| swab | genus | Lysobacter | 0.11 | 0.05 | 26 | 0.036 |
| swab | genus | Unclassified_Hyphomicrobiaceae | 0.11 | 0.05 | 26 | 0.036 |
| swab | genus | Mucilaginibacter | 0.12 | 0.05 | 26 | 0.037 |
| swab | genus | Pedobacter | 0.12 | 0.05 | 26 | 0.038 |
| swab | genus | Pseudoxanthomonas | 0.12 | 0.06 | 26 | 0.04 |
| swab | genus | Unclassified_Phormidiaceae | 0.12 | 0.06 | 26 | 0.041 |
| swab | genus | Frondihabitans | 0.12 | 0.06 | 26 | 0.043 |
| swab | genus | Unclassified_mitochondria | 0.12 | 0.06 | 26 | 0.044 |
| swab | genus | Aeromonas | 0.13 | 0.06 | 26 | 0.039 |
| swab | genus | Unclassified_Chlamydomonadaceae | 0.13 | 0.06 | 26 | 0.041 |
| swab | genus | Caulobacter | 0.15 | 0.06 | 26 | 0.013 |
| swab | genus | Clostridium_2 | 0.2 | 0.07 | 26 | 0.006 |
| swab | genus | Unclassified_Pseudomonadaceae | 0.27 | 0.12 | 26 | 0.036 |
| swab | genus | Unclassified_Xanthomonadaceae | 0.28 | 0.13 | 26 | 0.049 |
| swab | genus | Arthrobacter | 0.35 | 0.16 | 26 | 0.044 |
| swab | genus | Unclassified_Bradyrhizobiaceae | 0.49 | 0.23 | 26 | 0.047 |
| swab | genus | Other_Cyanobacteria | 0.89 | 0.32 | 26 | 0.009 |