Figure 3:

Stratification of patients for analysis over a period of approximately 2 years. 219 patients from various institutions underwent biopsy-free, next generation sequencing. We collected additional risk factor information for 102 patients, irrespective of alterations detected or not. Two correlation matrices were generated, independent of risk factor information. The first considered all patients, and all alteration types (Fig 3a, n=181 patients), and the second considered only patients with at least 1 alteration in an actionable gene and excluded VUS and synonymous alterations (Fig 3b, n=103 patients)