Table 3.
Task measures within the discontinuation group at baseline and seven weeks of youth who deteriorated clinically versus those who did not
| Measure |
Not deteriorated a n = 28 |
delta b |
Deteriorated a n = 19 |
delta b | Δ Change between groups c | Δ 95% CI | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 7 weeks | Baseline | 7 weeks | |||||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | |||||
| Working memory | ||||||||||||
| RT | 380 | 280 | 390 | 297 | 9.67 | 396 | 267 | 496 | 262 | 100 | 90.8 | 9.50, 172 |
| ER | 1.07 | 1.96 | 2.73 | 2.21 | 1.66 | 0.94 | 2.26 | 1.30 | 1.34 | 0.36 | 1.30 | 0.73, 1.87 |
| Response inhibition | ||||||||||||
| RT | 186 | 124 | 112 | 111 | −74.0 | 189 | 79.5 | 160 | 78.3 | −28.4 | 45.6 | 17.0, 74.2 |
| ER | 1.61 | 2.15 | 0.91 | 1.44 | −0.70 | 1.33 | 2.09 | 1.60 | 1.71 | 0.38 | 1.2 | 0.67, 1.73 |
| Attentional flexibility | ||||||||||||
| RT | 519 | 276 | 398 | 258 | −121 | 576 | 203 | 390 | 199 | −186 | 64.7 | −2.89, 132 |
| ER | 3.31 | 3.20 | 2.50 | 2.26 | −0.81 | 2.20 | 1.66 | 1.92 | 2.43 | −0.28 | 0.53 | −0.17, 1.23 |
| Psychomotor speed | ||||||||||||
| RT | 317 | 52.5 | 309 | 34.5 | −7.86 | 326 | 45.6 | 364 | 26.3 | 37.7 | 45.6 | 33.9, 57.3 |
RT, reaction time in milliseconds; ER, error rate; tasks see Table 2. p < .0074 using Bonferroni correction for multiple testing: none of the Δ changes between groups were significant.
a
‘Deteriorated’ = CGI‐I ≥ 6 (‘much worse’ and ‘very much worse’) and ‘not deteriorated’ all else.
b
The difference between seven weeks and baseline.
c
The difference in mean change from baseline to 7 weeks between the ‘deterioration’ and ‘nondeterioration’ group, by mixed models analyses.