Table 3.

Mean Amount of Total Radioactivity Excreted in Urine and Feces Following a Single Oral Dose of ¹⁴ C‐Ziritaxestat (Mass Balance Analysis Set)

Collection Interval (h)	Urine Aet(% of Administered Radioactivity) (n = 6)	Feces Aft(% of Administered Radioactivity) (n = 6)	Total At(% of Administered Radioactivity) (n = 6)
0‐4 a	0.45	…	0.45
4‐8 a	1.26	…	1.26
8‐12 a	1.65	…	1.65
12‐24 a /0‐24 b	1.27	5.40	6.67
24‐48	0.93	20.38	21.31
48‐72	0.43	14.83	15.26
72‐96	0.24	23.92	24.16
96‐120	0.16	7.76	7.92
120‐144	0.09	2.52	2.61
144‐168	0.07	1.00	1.07
168‐192	0.07	0.66	0.73
192‐216	0.04	0.47	0.51
216‐240	NC	0.34	0.37
240‐264	NC	0.12	0.12
264‐288	NC	NC	NC
	Ae% (SD)	Af% (SD)	At% (SD)
	6.68 (0.77)	77.42 (18.44)	84.1 (18.40)

¹⁴ C, carbon‐14; Ae%, amount of total radioactivity excreted in urine as a percentage of administered radioactivity; A_et, amount of total radioactivity excreted in urine up to time t; Af%, amount of total radioactivity excreted in feces as a percentage of administered radioactivity; A_ft, amount of total radioactivity excreted in feces up to time t; A_t, amount of total radioactivity excreted in urine and feces; At%, amount of total radioactivity excreted in urine and feces as a percentage of administered radioactivity; NC, not calculated; SD, standard deviation.

^a Collection interval in urine.

^b Collection interval in feces.