Table 4.
Summary of Major Metabolites Observed in Feces and Plasma
| Component | Retention Time (Minutes) | Mean Feces Region of Interest (%) | Mean Plasma Region of Interest |
|---|---|---|---|
| M620: Ring‐opened acid metabolite | 22.5 | 25.3 | NA |
| M590: Glycine conjugate of N‐dealkylated ziritaxestat | 23.0 | 25.3 | NA |
| M533: N‐dealkylated ziritaxestat | 23.2 | 25.3 | NA |
| M620: Ring‐opened azetidin‐3‐ol,mono‐hydroxy, desaturated (or keto) metabolite of ziritaxestat | 27.1 | 19.4 | NA |
| M604: Mono‐hydroxy ziritaxestat | 37.2 | 17.9 | 7.9 |
| M592: Ring‐opened azetidin‐3‐ol metabolite of N‐demethylated ziritaxestat | 37.6 | 17.9 | 3.3 |
| Ziritaxestat | 75.5 | 17.6 | 76.2 |
NA, not applicable (identification not applicable in this sample).