TABLE 2.
DASS‐42 anxiety and depression scores (adjusted means) by visit – change from baseline and treatment difference for two magnesium supplemented groups and overall ITT population
| Parameter | Statistics | Magnesium + vitamin B6 (N = 132) | Magnesium (N = 132) | Overall group a (N = 264) | Treatment difference |
|---|---|---|---|---|---|
| DASS‐42 anxiety | |||||
| Change from baseline to Week 4 | Adjusted mean (SE) | −5.69 (0.59) b | −6.02 (0.58) b | −5.86 (0.41) b | 0.26 (0.66) |
| Change from baseline to Week 8 | Adjusted mean (SE) | −8.45 (0.59) b | −9.03 (0.59) b | −8.74 (0.41) b | 0.54 (0.66) |
| DASS‐42 depression | |||||
| Change from baseline to Week 4 | Adjusted mean (SE) | −5.69 (0.65) b | −5.39 (0.69) b | −5.54 (0.47) b | −0.41 (0.75) |
| Change from baseline to Week 8 | Adjusted mean (SE) | −8.04 (0.65) b | −8.12 (0.69) b | −8.08 (0.47) b | −0.05 (0.75) |
Note: No significant differences (p < 0.05) in the change from baseline were identified between the magnesium + vitamin B6 group and magnesium group.
Change from baseline was calculated using MMRM including sex and visit as categorical fixed effects, DASS‐42 at baseline as continuous fixed effect and subject as random effect.
Treatment difference was calculated using MMRM including sex, visit, and treatment group as categorical fixed effects and DASS‐42 at baseline as continuous fixed effect, DASS‐42 at baseline x treatment group, visit x treatment group as interaction terms and subject as random effect.
Abbreviations: DASS‐42, Depression Anxiety Stress Scales; ITT, intent‐to‐treat; MMRM, Model Mixed for Repeated Measures; SE, standard error.
Overall group corresponds to the pooling of the magnesium + vitamin B6 group and magnesium group.
p‐value testing for a significant decrease within each treatment group. A p‐value < 0.05 was considered significant.