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Schematic representation of the consequences of Gal1 loss in the course of CLI in Mdr2‐KO mice. Loss of Gal1 exacerbates CLI, fibrosis, and liver injury starting from the early animal age. This, in turn, induces overexpression of proteins Ntrk2 (in hepatocytes at early age), S100A4 (in cholangiocytes at the middle age), and Opn (in cholangiocytes at all ages tested). Altogether, these activities culminate in earlier and enhanced tumorigenesis.
