Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 26;132(5):933–941. doi: 10.1002/lary.29766

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 RTI Health Solutions, Sanofi and Regeneron Pharmaceuticals, Inc. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Fig 1 — Five‐factor SNOT‐22 confirmatory factor analysis based on pooled phase 3 data at (A) baseline; (B) week 24. (A) *P < .01. Goodness‐of‐fit statistics for the five‐factor confirmatory factor analysis with no cross‐loading are as follows: CFI, 0.962; TLI, 0.956; RMSEA, 0.094 (95% CI 0.089–0.098). Minor modification to allow item 16 to load on both the Sleep and Function domains reduced RMSEA to 0.076 (0.071–0.081), with the strongest loading of this item (0.487) still on the Sleep domain. Items: 1. need to blow nose; 2. nasal blockage; 3. sneezing; 4. runny nose; 5. cough; 6. post‐nasal discharge; 7. thick nasal discharge; 8. ear fullness; 9. dizziness; 10. ear pain; 11. facial pain/pressure; 12. decreased sense of smell/taste; 13. difficulty falling asleep; 14. wake up at night; 15. lack of a good night's sleep; 16. wake up tired; 17. fatigue; 18. reduced productivity; 19. reduced concentration; 20. frustrated/restless/irritable; 21. sad; 22. embarrassed. (B) Goodness‐of‐fit statistics for the five‐factor confirmatory factor analysis with no cross‐loading are as follows: CFI, 0.975; TLI, 0.971; and RMSEA, 0.084 (95% CI, 0.079–0.089). Items: 1. need to blow nose; 2. nasal blockage; 3. sneezing; 4. runny nose; 5. cough; 6. post‐nasal discharge; 7. thick nasal discharge; 8. ear fullness; 9. dizziness; 10. ear pain; 11. facial pain/pressure; 12. decreased sense of smell/taste; 13. difficulty falling asleep; 14. wake up at night; 15. lack of a good night's sleep; 16. wake up tired; 17. fatigue; 18. reduced productivity; 19. reduced concentration; 20. frustrated/restless/irritable; 21. sad; 22. embarrassed. CFI = comparative fit index; CI = confidence interval; RMSEA = root mean square error of approximation; SNOT‐22 = 22‐item Sinonasal Outcome Test; TLI = Tucker‐Lewis index.