Table 1.

Subject characteristics and baseline measurements.

Characteristics	n = 14
Sex M/F	12/2
Methadone/buprenorphine	12/2
Age (median; 25th and 75th percentile)	48 (44–51)
ASI a	Average (SD)
Physical	0,85 (1,14)
Work	0,46 (0,78)
Alcohol	0,77 (1,48)
Drugs	3,23 (1,83)
Judicial	0,38 (1,12)
Family and social	0,46 (0,52)
Psychological and emotional	1,00 (1,22)
Total	1,02 (1,16)
Drug use b
Alcohol	2/14
Amphetamine	0/14
Benzodiazepines	3/14
Cannabis	4/14
Cocaine	7/14
Heroin	8/14
Tobacco	13/14
Baseline clinical measurements (25th and 75th percentiles)
Baseline median QTc	411 ms (387–434 ms)
Baseline median HR	70 bpm (63–80 bpm)
Baseline mean diastolic blood pressure	78 mmHg (75–88 mmHg)
Baseline mean systolic blood pressure	129 mmHg (119–146 mmHg)

^a Addiction severity index scores range from 0 to 4. A score of 0 means that the subject does not consider this domain a problem or needs no help, and a score of 4 means that the subject experiences the domain to be a big problem and would like help;

^b frequency of any drug use 1 month prior to detoxification. SD = standard deviation; bpm = beats per minute; HR = heart rate; M/F = male/female.