. 2022 Jul 14;14:71–82. doi: 10.2147/EB.S358384

Table 3.

Brain Cortical Structures Involved in Degenerative Ophthalmic Diseases in the Literature (PubMed Search Between 2000 and 2020)

Study	Country	N	Age	Design	Diagnosis	MRI analysis Method	Primary Outcome	Thinner Areas	Thicker Areas
*Glaucoma*
Boucard et al, 2009³¹	The Netherlands	8	72	Crosssectional	POAG	VBM	GM density	Fissure calcarine anteriorly
Chen et al, 2013⁴	China	30	43	Case-control	Advanced POAG	VBM	GM volume	Bilateral: G lingual, G calcarine, G postcentral, G superior frontal, G inferior frontal, rolandic operculum Right: G cuneus, G inferior occipital, G supramarginal Left: G paracentral
Li et al, 2012¹⁷	China	60	50	Case-control	Early / Advanced POAG	VBM	GM density	Bilateral: primary visual cortex, paracentral lobule Right: G precentral, G middle frontal, G inferior temporal, G angular Left: G precuneus, G middle temporal, G superior temporal
Frezzotti et al, 2016³⁴	Italia	25	52	Case-control	Advanced POAG	VBM	GM volume	Bilateral: hippocampus Right: G lingual, G lateral occipital, G superior parietal Left: cerebellum, G postcentral
Yu et al, 2013³⁵	China	76	47	Case-control	POAG	SBM	GM thickness	Bilateral: S calcarine Left: G middle temporal, G fusiform
Bogorodzki et al, 2014¹⁸	Poland	26	72	Case-control	Advanced POAG	SBM (FreeSurfer)	GM thickness	Bilateral: G lingual Right: G precentral, G superior temporal
Williams et al, 2013³⁶	USA	30	66	Case-control	POAG	VBM	GM volume	-	Bilateral: G occipital Right: G middle occipital, G inferior temporal
*Age-related macular degeneration*
Boucard, 2009³¹	The Netherlands	9	73	Crosssectional	AMD	VBM	GM density	Fissure calcarine posteriorly
*Cataract surgery*
Lou, 2013⁶	Denmark	12	71	Cohort	Unilateral cataract surgery	VBM	GM volume		Contralateral V2 (primary visual cortex)
*Oculomotor training*
Rosengarth, 2013³⁷	Germany	9	72	Cohort	Oculomotor training in AMD	VBM	GM density		Left posterior cerebellum

Abbreviations: N, study sample; MRI, magnetic resonance imaging; POAG, primary open angle glaucoma; VBM, voxel-based morphometry; SBM, surface based morphometry; GM, gray matter; AMD, age-related macular degeneration; G, gyrus; S, sulcus.