TABLE 2.
Biomarker characteristics
| Biomarker | Specification | Process | Cirrhosis | Alcohol‐related liver disease patients | Healthy | P |
|---|---|---|---|---|---|---|
| PRO‐C3 | Released N‐terminal pro‐peptide of type III collagen | Type III collagen formation | 34.9 (20‐48) | 14.6 (11‐24) | 8.2 (7‐9) | <0.001 |
| C3M | Neo‐epitope of MMP‐9 mediated degradation of type III collagen | Type III collagen degradation | 14.0 (11‐18) | 9.3 (8‐12) | 7.4 (6‐8) | <0.001 |
| PRO‐C4 | Internal epitope in the 7S domain of type IV collagen | Type IV collagen formation | 389.9 (320‐515) | 56.8 (35‐86) | 30.9 (24‐50) | <0.001 |
| C4M | Neo‐epitope of MMP‐2,9,12 mediated degradation of type IV collagen | Type IV collagen degradation | 154.6 (129‐213) | 31 (27‐39) | 27.4 (25‐34) | <0.001 |
| PRO‐C5 | Released C‐terminal pro‐peptide of type V collagen. | Type V collagen formation | — | 732.1 (585‐956) | 672.3 (542‐848) | 0.049 |
| C5M | Neo‐epitope of MMP‐2,9 mediated degradation of type V collagen | Type V collagen degradation | 168.3 (124‐242) | 6.3 (6‐7) | 6.2 (5‐8) | <0.001 |
| PRO‐C6 | C‐terminal of released C5‐domain of type VI collagen α3‐chain | Type VI collagen formation | — | 10.0 (8‐14) a | 7.3 (7‐8) | <0.001 |
| C6M | Neo‐epitope of MMP‐2 mediated degradation of type VI collagen | Type VI collagen degradation | 11.2 (9‐15) | 11.6 (9‐16) | 7.4 (6‐9) | <0.001 |
Characteristics of the collagen formation and degradation markers of extracellular matrix remodelling, and their levels in 281 patients with alcohol‐related liver disease vs 50 healthy controls matched for age, sex and BMI and 83 patients with alcohol‐related cirrhosis.
Serum concentrations (ng/mL) are reported as median and their interquartile range. P‐value reports comparisons between patients and healthy controls using the Mann‐Whitney U test for two‐group comparisons and Kruskal‐Wallis test for three‐group comparisons.
Abbreviation: MMP, matrix metalloproteinase.
PRO‐C6 data on 17 ALD patients are missing due to insufficient amount of serum for testing. PRO‐C5 and PRO‐C6 are not measured in the 83 cirrhosis patients.