FIGURE 2.

Heatmap and hierarchical clustering based on tau pathology in 1020 PSP and 199 CBD cases. The heatmap reflects the severity of tau pathology, and a colour scale is given at the top right. Each tau lesion type in a brain region is represented with rows, and each case is represented with columns. Two distinct clusters are identified by hierarchical clustering. The left cluster (Cluster 1) mainly contains CBD cases as shown in orange in the pathology label, while the right cluster (Cluster 2) mainly contains PSP cases as shown in blue in the pathology label. Cluster 2 can be divided into four clusters (Cluster 2–1, 2–2, 2–3 and 2–4). Pathologically confirmed CBD cases in Cluster 2 are noted as #1‐6. Note that Case 3 is located at the left end in Cluster 2–2. Abbreviations: AD, Alzheimer's disease; Astro, astrocytic tau lesions; Caudate, caudate nucleus; CB, coiled bodies; CBD, corticobasal degeneration; CBS, corticobasal syndrome; GP, globus pallidus; MBT, midbrain tectum; NFT, neurofibrillary tangle; Red, red nucleus; MBT, midbrain tectum; Motor, motor cortex; PSP, progressive supranuclear palsy; RS, Richardson syndrome; SN, substantia nigra; STN, subthalamic nucleus; Temp, temporal cortex; Threads, tau positive threads