TABLE 4.
Skin parameters of subjects
| Skin Parameters | Treatment | Placebo | P1 | P2 | P3 | Effect size (Test vs Placebo) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Week 6 | Week 12 | Baseline | Week 6 | Week 12 | Cohen's d [SD pooled ] | ||||
| R2 ratio (Cutometer®) | 0.57 ± 0.10 | 0.66 ± 0.09 | 0.72 ±0.10 | 0.61 ± 0.09 | 0.61 ± 0.12 | 0.61 ± 0.09 | .5770 | .2592 | <.0001 | 1.56 [0.10] |
| Melanin index (Mexameter MX18®) | 237.10 ± 62.60 | 236.30 ± 62.99 | 233.10 ± 57.13 | 231.50 ± 57.66 | 232.00 ± 56.02 | 230.00 ± 58.74 | >.999 | >.999 | >.999 | −0.11 [22.8] |
| Gloss DSC Value (Glossymeter GL200®) | 5.29 ± 1.23 | 5.43 ± 1.59 | 5.28 ± 1.19 | 5.49 ± 1.77 | 5.49 ± 1.57 | 5.41 ± 1.73 | >.999 | >.999 | >.999 | 0.055 [1.11] |
| Skin hydration (Corneometer CM825®) | 72.35 ± 7.06 | 76.02 ± 8.38 | 73.21 ± 7.64 | 73.62 ± 8.85 | 78.92 ± 7.15 | 77.77 ± 8.42 | >.999 | >.999 | .0412 | −0.45 [7.27] |
| TEWL (g/h/ m2) (Tewameter TM300®) | 11.70 ± 3.66 | 8.87 ± 3.24 | 10.52 ± 1.73 | 12.45 ± 3.50 | 9.74 ± 3.32 | 10.86 ± 2.02 | >.999 | >.999 | >.999 | 0.11 [3.51] |
| SELS parameters | ||||||||||
| SEsm | 212.70 ± 43.23 | 183.40 ± 33.27 | 170.70 ± 30.70 | 202.20 ± 42.02 | 199.60 ± 36.99 | 206.10 ± 42.73 | >.999 | .3386 | <.0001 | −1.33 [34.65] |
| SEr | 2.62 ± 1.01 | 3.09 ± 1.01 | 3.48 ± 1.10 | 2.71 ± 0.77 | 2.49 ± 0.56 | 2.53 ± 0.69 | .206 | .018 | .0001 | 1.53 [0.67] |
| SEsc | 0.62 ± 0.19 | 0.60 ± 0.11 | 0.57 ± 0.11 | 0.63 ± 0.10 | 0.64 ± 0.09 | 0.65 ± 0.10 | >.999 | >.999 | .0052 | −0.80 [0.095] |
| SEw | 76.21 ± 17.19 | 70.12 ± 13.90 | 65.12 ± 10.59 | 72.35 ± 15.42 | 72.78 ± 14.36 | 74.48 ± 14.50 | >.999 | >.999 | .0098 | −1.02 [13.68] |
Values are means ± SD. P1 = Comparison of mean between the two groups at baseline; P2 = Comparison of mean between the two groups at week 6; P3 = Comparison of mean between the two groups at week 12; Significant differences at p < .05. R2 ratio = skin elasticity; Cohen's d = baseline‐corrected difference between treatment and placebo means at completion. Bold indicates a large treatment effect size, with direction indication by sign.
Abbreviations: SEr, skin roughness; SEsc, skin scaliness; SEsm, skin smoothness; Sew, wrinkles; TEWL, trans‐epidermal water loss (g/h/m2).