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. 2021 Jul 14;40(23):5096–5114. doi: 10.1002/sim.9113

FIGURE 2.

SIM-9113-FIG-0002-b

Definitions of the six toxicity scenarios in terms of the probabilities of dose limiting toxicity (DLT), cytokine release syndrome (CRS), and other DLT (DLTo). For each scenario, the marginal probabilities of DLT, CRS, and DLTo of each dose regimen are represented as solid lines, while the conditional probabilities of DLTo given CRS and no CRS are represented as dotted lines. The target probability of DLT is represented by a dashed horizontal line