TABLE 2.

Proportions of selecting each dose regimen ${\mathit{S}}_{\mathit{k}}$ as the MTD‐regimen over the 1000 trials in the six main toxicity scenarios. For each scenario, the marginal probabilities of dose limiting toxicity (DLT), cytokine release syndrome (CRS), and other DLT (DLT_o) are defined, and the association between the CRS and DLT_o is represented by the average risk ratio (RR). Results are presented for the three joint approaches (DRtox_indep, DRtox_copula, and DRtox_cond) and the continual reassessment method (CRM). The proportions of correct selection (PCS) of the MTD‐regimen are represented in bold

Scenario	Set	RR	Method		${\mathit{S}}_{\mathbf{1}}$	${\mathit{S}}_{\mathbf{2}}$	${\mathit{S}}_{\mathbf{3}}$	${\mathit{S}}_{\mathbf{4}}$	${\mathit{S}}_{\mathbf{5}}$	${\mathit{S}}_{\mathbf{6}}$
1	A	1.85		${\mathit{p}}_{\mathit{T}}$	0.10	0.14	0.18	0.30	0.45	0.60
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{1})}$	0.05	0.07	0.1	0.18	0.22	0.30
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{2})}$	0.06	0.08	0.1	0.17	0.34	0.50
			DRtox_indep		0	4	24	55	16	2
			DRtox_copula		0	2	20	55	20	3
			DRtox_cond		0	3	25	55	16	2
			Logistic CRM		0	4	22	46	22	5
2	A	5.91		${\mathit{p}}_{\mathit{T}}$	0.10	0.13	0.18	0.30	0.42	0.53
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{1})}$	0.07	0.10	0.13	0.22	0.28	0.36
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{2})}$	0.04	0.07	0.10	0.21	0.39	0.52
			DRtox_indep		0	4	27	48	16	3
			DRtox_copula		0	3	17	52	24	5
			DRtox_cond		0	3	23	52	18	4
			Logistic CRM		0	4	18	42	26	10
3	A	1.81		${\mathit{p}}_{\mathit{T}}$	0.11	0.15	0.18	0.30	0.45	0.59
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{1})}$	0.03	0.05	0.07	0.13	0.16	0.23
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{2})}$	0.08	0.11	0.13	0.22	0.39	0.54
			DRtox_indep		1	3	22	57	15	2
			DRtox_copula		1	2	16	58	20	2
			DRtox_cond		1	3	22	58	15	2
			Logistic CRM		1	5	22	48	19	5
4	A	1.90		${\mathit{p}}_{\mathit{T}}$	0.09	0.13	0.17	0.30	0.44	0.59
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{1})}$	0.07	0.10	0.13	0.23	0.29	0.37
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{2})}$	0.03	0.04	0.06	0.12	0.27	0.43
			DRtox_indep		0	3	24	56	14	2
			DRtox_copula		0	2	19	56	20	4
			DRtox_cond		0	3	24	55	15	2
			Logistic CRM		0	4	20	46	23	7
5	A	1.97		${\mathit{p}}_{\mathit{T}}$	0.03	0.04	0.05	0.11	0.17	0.30
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{1})}$	0.02	0.03	0.05	0.09	0.11	0.17
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{2})}$	0.00	0.01	0.01	0.02	0.08	0.18
			DRtox_indep		0	0	0	4	29	67
			DRtox_copula		0	0	0	3	20	77
			DRtox_cond		0	0	0	4	29	67
			Logistic CRM		0	0	0	2	21	77
6	B	1.70		${\mathit{p}}_{\mathit{T}}$	0.16	0.30	0.43	0.55	0.73	0.86
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{1})}$	0.09	0.17	0.25	0.33	0.38	0.48
				${\mathit{p}}_{\mathit{T}}^{(\mathbf{2})}$	0.08	0.18	0.29	0.41	0.67	0.84
			DRtox_indep		20	64	15	1	0	0
			DRtox_copula		14	63	21	2	0	0
			DRtox_cond		19	65	15	1	0	0
			Logistic CRM		17	56	24	3	0	0