. 2021 Jul 14;40(23):5096–5114. doi: 10.1002/sim.9113

TABLE B1.

Definition and value of the pharmacokinetics and pharmacodynamics (PK/PD) parameters used for the simulation study. Parameter estimate represents the fixed effect, and the coefficient of variation (CV) is the square root of the diagonal of the variance‐covariance matrix. These values are inspired by the parameters estimated on blinatumomab, ³¹ , ⁴⁶ with a modification of I_max to observe cytokine mitigation after several administrations

	Parameter	Estimate (% CV)	Unit	Description
PK model	Cl	1.36 (41.9)	L/h	Clearance of elimination
PK model	V	3.4 $(0)$	L	Volume of distribution
PD model	E $_{\max}$	3.59 . 10⁵ (14)	pg/mL/h	Maximum cytokine release rate
	EC₅₀	1.10⁴ (0)	ng/mL	Drug exposure for half‐maximum release
	H	0.92 $(3)$		Hill coefficient for cytokine release
	I_max	0.995 $(0)$		Maximum inhibition of cytokine release
	IC₅₀	$1.82 \cdot 1 0^{4}$ (12)	pg/mL $\cdot$ h	Cytokine exposure for half‐maximum inhibition
	k_deg	0.18 $(13)$	h⁻¹	Degradation rate for cytokine
	K	2.83 $(36)$		Priming factor for cytokine release