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Overview of the study. TLR22-induced Ca2+ influx into mitochondria triggers mtROS generation leading to downstream activation of HIF-1α/CHOP axis. Activated CHOP instigates UPRmt-mediated fragmentation of the mitochondrial network leading to mitochondrial dysfunction which activates caspase-9/caspase-3 axis-mediated apoptosis of A. hydrophila-infected HKM.
