FIGURE 4.
Time course of runcaciguat‐induced dilation of angiotensin II (Ang II) pre‐constricted glomerular arterioles. Glomerular arterioles were pretreated with L‐NAME (10−4 M) and pre‐constricted with Ang II (10−12 to 10−6 M), as shown before. Then, runcaciguat (10−7 M; ‘L‐NAME + runcaciguat’) or DMSO (‘L‐NAME + vehicle’) were applied and diameter changes of (a) afferent arterioles and (b) efferent arteriole were monitored over 10 min. Data represent mean ± SD. n values are indicated in parentheses. The colour code given in panel (b) corresponds to the experimental groups indicated in panel (a). *P < 0.05