Table 2.
Top five significantly differentially expressed proteins, based on cohort 1, detected by PEA, comparing (P)VRL with all other aetiologies, sarcoid uveitis with TB‐associated uveitis and granulomatous (sarcoid and TB) uveitis with all other aetiologies
| Protein | p‐value | FDR adjusted p‐value | ∆ NPX | Fold change |
|---|---|---|---|---|
| (P)VRL versus other aetiologies | ||||
| EZR | 2.1E‐12 | 3.5E‐10 | 3.2 | 1.9 |
| ISOLD | 1.5E‐09 | 1.2E‐07 | n/a | n/a |
| CCL8 | 1.7E‐05 | 9.5E‐04 | 2.5 | 1.5 |
| IL‐10/IL‐6.ratio | 1.2E‐04 | 5.1E‐03 | n/a | n/a |
| CCL2 | 2.6E‐04 | 7.6E‐03 | 1.3 | 1.1 |
| Sarcoidosis versus TB‐associated | ||||
| CCL17 | 9.9E‐06 | 1.7E‐03 | 3.9 | 4.2 |
| CXCL13 | 1.6E‐04 | 1.3E‐02 | 3.2 | 1.7 |
| Granulomatous (sarcoidosis and TB‐associated) versus other aetiologies | ||||
| EZR | 1.5E‐04 | 2.4E‐02 | −1.8 | 0.6 |
| CD8A | 4.5E‐04 | 2.4E‐02 | −1.7 | 0.4 |
| GZMB | 5.4E‐04 | 2.4E‐02 | −2.1 | 0.4 |
| GZMH | 6.8E‐04 | 2.4E‐02 | −2.1 | 0.5 |
| CRTAM | 9.9E‐04 | 2.4E‐02 | −1.2 | 0.1 |
(P)VRL = primary vitreoretinal lymphoma, FDR = false discovery rate, NPX = normalized protein expression, PEA = proximity extension assay, TB = tuberculosis.