Table 3.
Optimal sensitivity and specificity as determined by Youden’s index calculation, based on cohort 1, comparing (P)VRL with all other aetiologies, sarcoid uveitis with TB‐associated uveitis and granulomatous with all other aetiologies.
| Protein | Youden’s index | Sensitivity | Specificity | AUC | Cut‐off value |
|---|---|---|---|---|---|
| (P)VRL versus other aetiologies | |||||
| EZR | 0.98 | 1.00 | 0.98 | 0.99 | 5.90 |
| ISOLD | 1.00 | 1.00 | 1.00 | 1.00 | −10.07 |
| CCL8 | 0.68 | 0.86 | 0.83 | 0.82 | 6.79 |
| IL‐10/IL‐6 ratio | 1.00 | 1.00 | 1.00 | 1.00 | 0.79 |
| CCL2 | 0.66 | 0.86 | 0.80 | 0.84 | 12.88 |
| FasL | 0.70 | 1.00 | 0.70 | 0.90 | 4.45 |
| CXCL13 | 0.78 | 0.86 | 0.93 | 0.90 | 10.74 |
| CASP.8 | 0.78 | 1.00 | 0.78 | 0.88 | 6.84 |
| IL‐10 | 1.00 | 1.00 | 1.00 | 1.00 | 4.88 |
| CD40 | 0.88 | 1.00 | 0.88 | 0.94 | 10.11 |
| GZMH | 0.63 | 0.86 | 0.78 | 0.87 | 4.28 |
| CD70 | 1.00 | 1.00 | 1.00 | 1.00 | 3.52 |
| GZMB | 0.63 | 0.86 | 0.78 | 0.87 | 3.85 |
| Sarcoidosis versus TB‐associated | |||||
| CCL17 | 0.45 | 0.67 | 0.78 | 0.70 | 5.22 |
| CXCL13 | 0.18 | 0.87 | 0.31 | 0.47 | 5.77 |
| Granulomatous (sarcoidosis and TB‐associated) versus other aetiologies | |||||
| EZR | 0.55 | 0.89 | 0.67 | 0.80 | 3.04 |
| CD8A | 0.47 | 0.62 | 0.86 | 0.76 | 1.57 |
| GZMB | 0.47 | 0.62 | 0.86 | 0.77 | 3.47 |
| GZMH | 0.49 | 0.73 | 0.76 | 0.75 | 3.07 |
| CRTAM | 0.51 | 0.65 | 0.86 | 0.79 | 1.28 |
| PDGFR‐α | 0.54 | 0.54 | 1.00 | 0.73 | 1.89 |
| CD5 | 0.44 | 0.54 | 0.91 | 0.75 | 3.21 |
| FasL | 0.46 | 0.65 | 0.81 | 0.76 | 4.30 |
| VEGFC | 0.52 | 0.62 | 0.91 | 0.74 | −0.49 |
| PDCD1 | 0.48 | 0.58 | 0.91 | 0.77 | 1.50 |
| ADA | 0.46 | 0.65 | 0.81 | 0.76 | −0.15 |
| CD40 | 0.49 | 0.54 | 0.95 | 0.75 | 9.71 |
| CCL8 | 0.44 | 0.54 | 0.91 | 0.76 | 6.39 |
| CD70 | 0.58 | 0.77 | 0.81 | 0.82 | 1.08 |
| GZMA | 0.45 | 0.69 | 0.76 | 0.75 | 4.41 |
| NCR1 | 0.40 | 0.54 | 0.86 | 0.69 | 1.33 |
(P)VRL = primary vitreoretinal lymphoma, AUC = area under the curve, TB = tuberculosis.