. 2021 Oct 13;88(3):1235–1245. doi: 10.1111/bcp.15068

TABLE 3.

True positives and false positives per search strategy identifying ADRs

Number	Search strategies	Included trigger words		TPs		FPs		PPV
				n	%	n	%	%
S1	Keywords implying an ADR	Conjugations of	Drug‐induced	20	10	5	1	80
			Allergy	17	8	80	21	18
			Side effect	21	10	10	3	68
			Intolerance	0	0	0	0	n/a
			Reaction	1	0	2	1	33
			Toxicity	13	6	1	0	93
S1 Total/overall ADRs found by keywords				72	35	98	26	42
S2a	Prepositions followed closely ^b by a drug group ^c , a generic drug name, a drug brand, trade name or abbreviation a drug, or drug therapy ^d	Conjugations of	By	16	8	19	5	41
			With	55	27	44	12	56
			After	12	6	67	18	15
			Of	31	15	62	16	33
			On	5	2	73	19	6
			Since	2	1	12	3	14
S2b	Abbreviations using the included prepositions	Conjugations of	As a result of/because of	0	0	1	0	0
			Based on	3	1	0	0	100
			As a consequence of	4	2	1	0	80
S2 Total/overall ADRs found by a combination of predisposition and drug name				128	62	278	74	31
S3	Content of forms labelled ^a	Conjugations of	Allergies:	0	0	0	0	n/a
S3	Content of forms labelled ^a	Conjugations of	Anaphylaxis:	0	0	0	0	n/a
S3 Total/overall ADRs found in labelled allergy and anaphylaxis forms				0	0	0	0	n/a
S4	Content of complication registration containing key field drug‐induced	…	…	0	0	0	0	n/a
S5	Content of ADR module	…	…	6	3	0	0	100
S5 Total/overall ADRs found in ADR module				6	3	0	0	100
Total ADRs identified				206	100	377	100	35

Abbreviations: Adr, adverse drug reaction; FP, false positive; PPV, positive predicted value; TP, true positive.

^{^a}

Forms labelled allergy and anaphylaxis using free‐text entries were applied prior to the ADR module's introduction in 2015.

^{^b}

The maximum number of characters (ie, proximity between a preposition and drug name) was set at 16.

^{^c}

The drug group names were based on the Anatomical Therapeutic Chemical (ATC) therapeutic subgroup, pharmacological subgroup, chemical subgroup or chemical substance (ie, second to fifth levels of ATC main groups classified by WHO).

^{^d}

Examples are PPI (proton‐pump inhibitor), HCTZ (hydrochlorothiazide), FOLFOX (combination therapy of fluorouracil and oxaliplatin). A full list of abbreviations is provided in Table S2.