Table 3.
Mutations identified between vaccine strains and vaccine‐associated viruses involved in altering the reading frame. The position of each SNP is provided for KX764645_Neethling‐LSD‐Vaccine‐OBP and AF409137_Neethling‐LSD‐Warmbaths‐RSA‐2000
| # | Nucleotide in vaccine strains (KX764645_Neethling‐LSD‐Vaccine‐OBP) | Nucleotide in vaccine‐associated viruses | Nucleotide in wild type (AF409137_Neethling‐LSD‐Warmbaths‐RSA‐2000) | ORF affected | Amino acid position in protein |
|---|---|---|---|---|---|
| 1 | 13,403 (–) | A | 13,412 (A) | LW019 | 124 |
| 2 | 68,066 (A) | – | 68,095 (–) | LW086 | 206 |
| 3 | 81,108 (T) | C | 81,131 (C) | LW087 | 198 |
| 4 | 81,110 (T) | A | 81,133 (A) | LW087 | 198 |
| 5 | 81,111 (T) | – | 81,134 (–) | LW087 | 198 |
| 6 | 105,629 (A) | – | 105,695 (–) | LW114 | 168 |
| 7 | 119,429 (–) | T | 119,523 (T) | LW131 | 83 |
| 8 | 124,248 (A) | – | 124,343 (–) | LW134 | 721 |