TABLE 4.
Association Between Pre‐stroke Aspirin Use and Early Neurological Deterioration a
| Aspirin users POM, % (95% CI) b (n = 2,727.1) | Aspirin nonusers POM, % (95% CI) b (n = 2,972.9) | Risk difference, % (95% CI) b , c | Odds ratio (95% CI) d | |
|---|---|---|---|---|
| All patients | 9.9 (7.3 to 12.5) | 11.3 (10.4 to 12.2) | −1.4 (−4.1 to 1.4) | 0.86 (0.72 to 1.03) |
| p value | 0.33 | 0.10 | ||
| Subtypes | ||||
| LAA | 12.5 (8.6 to 16.4) | 12.2 (10.9 to 13.5) | 0.3 (−3.9 to 4.5) | 1.07 (0.85 to 1.34) |
| p value | 0.89 | 0.59 | ||
| SVO | 7.6 (2.4 to 12.8) | 8.7 (7.1 to 10.2) | −1.1 (−6.5 to 4.3) | 0.79 (0.55 to 1.14) |
| p value | 0.70 | 0.21 | ||
| CE | 7.1 (4.3 to 9.9) | 12.5 (10.3 to 14.8) | −5.4 (−8.9 to −1.9) | 0.52 (0.34 to 0.78) |
| p value | 0.002 | 0.002 | ||
| p value e | 0.009 |
Five thousand seven hundred patients were included (2,987 large artery atherosclerosis, 1,548 small vessel occlusion, and 1,174 cardioembolism).
Potential outcome means (95% CI) and risk differences (95% CI) are from “doubly robust” 27 inverse probability weighting analysis adjusted for age, sex, stroke subtypes, admission NIHSS score, hypertension, diabetes, hyperlipidemia, smoking, atrial fibrillation, coronary artery disease, pre‐stroke mRS score, pre‐stroke statin use, pre‐stroke antihypertensive use, pre‐stroke antidiabetic use, log‐transformed infarct volume, and onset to MRI.
Risk differences are for pre‐stroke aspirin users relative to pre‐stroke aspirin nonusers.
Adjusted odds ratios and 95% CIs are from multivariable logistic regression analysis in the inverse probability weighted data adjusted for age, sex, stroke subtypes, admission NI HSS score, hypertension, diabetes, hyperlipidemia, smoking, atrial fibrillation, coronary artery disease, pre‐stroke mRS score, pre‐stroke statin use, pre‐stroke antihypertensive use, pre‐stroke antidiabetic use, log‐transformed infarct volume, and time from onset to MRI.
The p value for interaction between pre‐stroke aspirin use and stroke subtypes and from a multivariable logistic regression analysis in the inverse probability weighted data with adjustment for covariates.
CE = cardioembolism; CI = confidence interval; LAA = larger artery atherosclerosis; MRI = magnetic resonance imaging; mRS = modified Rankin Scale; NIHSS = National Institute of Health Stroke Scale; POM = potential outcome mean; SVO = small vessel occlusion.