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. 2021 Jul 31;158(5):1110–1130. doi: 10.1111/jnc.15468

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© 2021 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Nuclear factor erythroid 2 (NFE2)‐related factor 2 (Nrf2) significantly translocates from the cytoplasm to the nucleus after tumour inoculation. (a–c) Western blot analysis revealed dynamic changes in Nrf2 expression in the spinal cord cytoplasm (a and b) and nucleus(a and c) after tumour inoculation(*p < .05, **p < .01,***p < .001 vs. sham group; n = 4, one‐way ANOVA). (d) Subcellular localization of Nrf2 in the dorsal horn of the spinal cord of rats with bone cancer pain (BCP) (red). DAPI (blue) was used to label the nucleus. High‐magnification images of immunofluorescence are indicated in the white box. Lumbar enlargements were collected on day 12 after the operation or tumour inoculation; n = 4. Scale bar: 50 μm. n represents the number of experimental animals in each group