Table 3.

Dose Proportionality Analysis of AUC and C_max for Baricitinib Following Single Oral Doses of 2 to 10 mg on Day 1 and Multiple Oral Doses of 2 to 10 mg on Day 10 in Healthy Chinese Subjects

Single Oral Doses of 2 to 10 mg on Day 1
Parameter	Power Model Equation	90%CI of Exponent	Baricitinib Dose (mg)	Predicted Dose‐Normalized Geometric Means	Ratio of Dose‐Normalized Geometric Means (10 or 4 mg vs 2 mg) (90%CI)
AUC0‐∞, ng · h/mL	(e4.16):(Dose1.08)	1.01‐1.14	2	67.43
			4	71.03	1.05 (1.00‐1.11)
			10	76.09	1.13 (1.01‐1.26)
Cmax, ng/mL	(e2.37):(Dose1.12)	0.96‐1.28	2	11.67
			4	12.71	1.09 (0.97‐1.22)
			10	14.23	1.22 (0.94‐1.58)
Multiple oral doses of 2 to 10 mg on Day 10
AUCτ,ss, ng . h/mL	(e4.21):(Dose1.04)	0.96‐1.13)	2	69.44
			4	71.60	1.03 (0.97‐1.09)
			10	74.56	1.07 (0.94‐1.23)
Cmax,ss, ng/mL	(e2.59):(Dose0.99)	0.87‐1.22	2	13.25
			4	13.17	0.99 (0.91‐1.08)
			10	13.07	0.99 (0.81‐1.20)

AUC, area under the plasma concentration–time curve; AUC_0‐∞, area under the plasma concentration–time curve from time zero to infinity; AUC_τ,ss, area under the plasma concentration–time curve during one dosing interval at steady state; CI, confidence interval; C_max, maximum observed drug concentration; C_max,ss, maximum observed drug concentration at steady state.

Model: Log (Parameter) = Log (Dose) + Random Error.